Next to methamphetamine,1 cocaine creates the greatest psychological dependence of any drug. It stimulates key pleasure centers within the brain and causes extremely heightened euphoria.
A tolerance to cocaine develops quickly—the addict soon fails to achieve the same high experienced earlier from the same amount of cocaine.
Cocaine is sometimes taken with other drugs, including tranquilizers, amphetamines,2 marijuana and heroin. Such combinations greatly increase the danger of using cocaine. In addition to the likelihood of developing a two-drug habit, one can easily create a mixture of narcotics that proves fatal.